MEK-IN-7

SKU: orb3174649

Description

MEK-IN-7 (compound WX086) is a potent, orally bioavailable, selective MEK inhibitor with an MEK1 IC50 of 29.62 nM. It effectively inhibits cell proliferation in HT29 and A375 cells, with IC50 values of 0.62 nM and 0.40 nM, respectively, and suppresses tumor growth in HL-29 xenograft mouse models. MEK-IN-7 is applicable in melanoma and colon cancer research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2256822-22-5
• MW: 649.48
• Formula: C₂₇H₂₅FIN₃O₅S
• SMILES: O=C1OC2=C(C(=O)N(C(=C2C=3C=CC=C(NS(=O)(=O)C)C3C)C)C4CC4)C(NC5=CC=C(I)C=C5F)=C1C
• Target: MEK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MEK