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Meglitinide

SKU: orb3210768

Description

Meglitinide is an ATP-sensitive potassium (KATP) channel inhibitor with IC50 values of 0.26 μM for SUR1, 0.53 μM for SUR2A, and 1.6 μM for SUR2B. It exhibits a Kd of 7 μM for SUR1 and SUR2A, and 8 μM for SUR2B, binding with high affinity to the SUR1, SUR2A, and SUR2B subunits to close KATP channels. It targets a binding site common to all SUR isoforms, and its interaction with the SUR1 subunit carrying the S1237Y mutation remains unchanged. Meglitinide is applicable in research related to type 2 diabetes.

Images & Validation

Key Properties

CAS Number54870-28-9
MW333.77
FormulaC17H16ClNO4
SMILESO=C(O)C1=CC=C(C=C1)CCNC(=O)C2=CC(Cl)=CC=C2OC
TargetPotassium Channel

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information