Megestrol acetate

SKU: orb1224538

Description

Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast Y. Megestrol acetate has been approved to treat anorexia and cachexia. (In Vitro):Megestrol acetate alone results in an ICKY of 48.7 p,M in the MCF7/ADR cell line.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 595-33-5
• MW: 384.51
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₂O₄
• SMILES: CC(O[C@]1(C(C)=O)CC[C@@]2([H])[C@]3([H])C=C(C)C4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O
• Target: Estrogen Receptor/ERR
• Solubility: Ethanol: 15 mg/mL (39.01 mM); DMSO: 33 mg/mL (85.82 mM)

Bioactivity

• In Vivo:
  Megestrol acetate (100 or 300 mg/kg, Subcutaneously daily over a 7-day period) is able to reduce the weight loss produced by both TNF and by the MAC16 tumour. Animal model: Pure strain female NMRI mice (age 6 to 8 weeks). Dosage: 100 or 300 mg/kg (50 mg megestrol acetate was suspended in 3 ml of pure corn oil). Administration: Subcutaneously daily over a 7-day period. Result: Produced a highly significant reversal of the TNF-induced decrease in body weight, accompanied by a significant increase in both food and water intake. Caused an increase in body weight over a 24-hour period to female NMRI mice. No effect on blood glucose levels in saline controls, concurrent administration of megestrol acetate with TNF caused a significant increase in blood glucose compared with administration of TNF alone. Caused a dose-related reduction in the loss of host body weight in animals bearing the MAC16 tumour.
• In Vitro:
  Megestrol acetate alone results in an ICKY of 48.7 p, M in the MCF7/ADR cell line.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Megestrol Acetate | NSC 71423 | SC-10363

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR