Medicarpin

SKU: orb1297289

Description

N-Methylnicotinamide is an endogenous metabolite known to mitigate endothelial dysfunction. It serves as a key research tool for studying vascular biology and metabolic disorders in both in vitro cellular assays and in vivo models of cardiovascular disease.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 32383-76-9
• MW: 270.28
• Purity: 99.86% (May vary between batches)
• Formula: C₁₆H₁₄O₄
• SMILES: [H][C@@]12COc3cc(O)ccc3[C@]1([H])Oc1cc(OC)ccc21
• Target: JNK,ROS,Bcl-2 Family,Apoptosis
• Solubility: DMSO:22.5 mg/mL (83.25 mM)

Bioactivity

• In Vitro:
  To this aim, 7- and 30-day-old plants were treated with 0, 120, 240, 500, and 1,000 μM Pb during 10 days. The content of Medicarpin was determined by HPLC, and the extent of Medicarpin production was deduced from the result of semiquantitative RT-PCR performed on PAL, CHS, and VR genes. HPLC results indicated that Medicarpin concentration has been reduced in the roots, while its exudation to the culture medium has been increased. RT-PCR results indicated that the transcript levels of PAL, CHS, and VR genes have not been affected following Pb stress in seedlings. At the vegetative stage, transcript levels of PAL and CHS genes have been reduced in the roots. However, the transcript level of VR gene increased at 120 and 240 μM Pb, while it decreased at higher concentrations. In the shoot, the transcript levels of PAL, CHS, and VR genes were increased following increased concentration of lead in the medium
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bcl-2, Apoptosis, inhibit, JNK, Inhibitor, Medicarpin, ROS

Compound Identifiers

PubChem CID

336327