Mecamylamine hydrochloride

SKU: orb1223930

Description

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Key Properties

• CAS Number: 826-39-1
• MW: 203.75
• Purity: >98% (HPLC)
• Formula: C₁₁H₂₂ClN
• SMILES: CC1(C)C(NC)(C)C2CCC1C2.[H]Cl
• Target: AChR
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  Animal model: Choroidal neovascularization (CNV) mice model. Dosage: 50 mg/kg/day, 2 days. Administration: Subcutaneous pumps implanted beneath the skin of the back, 200 μL and mean pumping rate of 0.5 μL/h. Result: Suppressed the development of CNV at Bruch’s membrane rupture sites in the absence of nicotine. Animal model: C57BL/6J mice. Dosage: 0.5-1 mg/kg. Administration: Intraperitoneal injection. Result: Had no effect in β2 knockout mice and α7 knockout mice, but decreased immobility time in wildtype littermates in the FST.
• In Vitro:
  Western blot analysis. Cell line: SCG neurons. Concentration: 10 μM. Incubation time: 48 h. Result: Reduced the nicotine-facilitated increase in ERK1/2.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inversine

Quick Database Links

Gene Symbol

AChR