MDR-1339

SKU: orb1296260

Description

MDR-1339

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1018946-38-7
• MW: 326.39
• Purity: 98.57%
• Formula: C₂₀H₂₂O₄
• SMILES: COCCCc1ccc2oc(cc2c1)-c1ccc(OC)c(OC)c1
• Target: Gamma-secretase,Beta Amyloid
• Solubility: DMSO:40 mg/mL (122.55 mM);10% DMSO+90% Corn Oil:2 mg/mL (6.13 mM)

Bioactivity

• In Vivo:
  MDR-1339 (0.1-10 mg/kg, p.o.) dose-dependently restores passive avoidance responses in Alzheimer's disease mice models (ED50: 0.19 mg/kg) and significantly improves spontaneous alternation while reducing Aβ1-40 and Aβ1-42 levels in APP/PS1 mice at 30 and 100 mg/kg, p.o. Daily for 8 weeks.
• In Vitro:
  MDR-1339 shows no significant Inhibition of a panel of CYP isozymes, while it slightly inhibits CYP2C8 IC50 31.4 μM). MDR-1339 (1.5-10 μM) protects cells from this Aβ-induced toxicity. MDR-1339 (3.1 50 μM) also dose-dependently block the formation of Aβ aggregates and disaggregates Aβ fibrils.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

β Amyloid, βAmyloid, β-amyloid peptide, Beta Amyloid, BetaAmyloid, DWK-1339, DWK 1339, DWK1339, Abeta, bAmyloid, Amyloid-β, b Amyloid, Aβ, inhibit, MDR1339, MDR-1339, MDR 1339, Inhibitor, Gammasecretase

Compound Identifiers

PubChem CID

24764491