MD-224

SKU: orb1309440

Description

MD-224

Research Area

Cell Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 2136247-12-4
• MW: 889.8
• Purity: 99.07% (May vary between batches)
• Formula: C₄₈H₄₃Cl₂FN₆O₆
• SMILES: O=C1[C@@]2([C@]3(N[C@@H](C(NC4=CC=C(C(NCCCC#CC5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5)=O)C=C4)=O)[C@@H]2C8=C(F)C(Cl)=CC=C8)CCCCC3)C=9C(N1)=CC(Cl)=CC9
• Target: PROTACs,E1/E2/E3 Enzyme,MDM-2/p53,Mdm2
• Solubility: DMSO:150 mg/mL (168.58 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.62 mM)

Bioactivity

• Target IC50:
  MDM2:1 nM (IC50)
• In Vivo:
  MD-224 achieves complete and durable tumor regression in vivo in the RS4;11 xenograft tumor model in mice at well-tolerated dose schedules.
• In Vitro:
  MD-224 effectively induces rapid degradation of MDM2 at concentrations <1 nM in human leukemia cells. It achieves an IC50 value of 1.5 nM in inhibition of growth of RS4;11 cells and also low nanomolar IC50 values in a panel of leukemia cell lines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cancer, E1Enzyme, E1/E2/E3 Enzyme, E1 Enzyme, E1 activating enzyme, E2 Enzyme, E2 conjugating enzyme, E2Enzyme, E3Enzyme, E3 ligating enzyme, E3 Enzyme, leukemia, MDM-2/p53, Mdm2, MD 224, MD224, MD-224, Inhibitor, inhibit, RS4;11, PROTACs, PROTAC, Ubiquitin ligase, Ubiquitin conjugating enzyme, Ubiquitin activating enzyme

Compound Identifiers

PubChem CID

131986956