MCT1-IN-3

SKU: orb1741448

Description

MCT1-IN-3 is a potent small molecule inhibitor of monocarboxylate transporter 1 (MCT1/SLC16A1), exhibiting an IC50 of 81.0 nM. It also shows significant activity against the ABCB1 multidrug transporter. This compound is a valuable research tool for studying cancer metabolism and multidrug resistance in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2878360-80-4
• MW: 389.4
• Purity: 99.35% (May vary between batches)
• Formula: C₂₂H₁₉N₃O₄
• SMILES: C(=C(C(OC)=O)C#N)C=1C=2C(N(CC(NC3=CC=C(OC)C=C3)=O)C1)=CC=CC2
• Target: Monocarboxylate transporter,P-gp
• Solubility: DMSO:22.5 mg/mL (57.78 mM)

Bioactivity

• Target IC50:
  MCT1:81nM
• In Vitro:
  MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI50 values of 20 μM and 15.1 μM, respectively. Treatment with MCT1-IN-3 5μM for 24 h significantly leads to cancer cell cycle arrest as well as apoptosis, which has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Monocarboxylate transporter, Monocarboxylatetransporter, MCT1, MCT1IN3, MCT1-IN-3

Compound Identifiers

PubChem CID

171340819