MCP110

SKU: orb1305478

Description

MCP110 is a small molecule inhibitor that disrupts the Ras-Raf-1 protein-protein interaction. It serves as a valuable research tool for investigating Ras signaling pathways in oncology, with applications in both in vitro biochemical assays and in vivo tumor model studies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 521310-51-0
• MW: 508.65
• Purity: 97.23% (May vary between batches)
• Formula: C₃₃H₃₆N₂O₃
• SMILES: COc1cc(CN(CCc2ccccn2)C(=O)CCCCc2ccccc2)ccc1OCc1ccccc1
• Target: Raf,Ras
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.83 mM);DMSO:245 mg/mL (481.67 mM)

Bioactivity

• In Vitro:
  In A549 cells, MCP110 (20 μM) decreases Ras stimulation of Raf-1 and cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL), and serum. In in HEK293 cells, MCP110 (10 and 20 μM) inhibits H-Ras (V12)-induced AP-1 activation. In fibrosarcoma HT1080 cells, MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

colorectal, cancer, astrocytomas, Inhibitor, inhibit, MCP110, MCP-110, MCP 110, Raf kinases, Raf, Raf-1, Ras

Compound Identifiers

PubChem CID

10229237