MCOPPB triHydrochloride

SKU: orb1306561

Description

MCOPPB triHydrochloride is a potent and selective agonist for the nociceptin/orphanin FQ peptide (NOP) receptor. This small molecule is a valuable research tool for investigating the NOP receptor's role in pain, anxiety, and depression through both in vitro binding assays and in vivo behavioral studies.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1108147-88-1
• MW: 518.01
• Purity: 99.89%
• Formula: C₂₆H₄₃Cl₃N₄
• SMILES: Cl.Cl.Cl.CC1(CCCCCCC1)N1CCC(CC1)n1c(nc2ccccc12)[C@@H]1CCCNC1
• Target: Opioid Receptor
• Solubility: H2O:16.02 mg/mL (30.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.86 mM);DMSO:32.04 mg/mL (61.85 mM)

Bioactivity

• Target IC50:
  Nociceptin receptor:10.07 (pKi)
• In Vivo:
  Only Parthenolide, the HDAC inhibitor with anti-inflammatory features, displayed a potent anti-apoptotic effect in Phb1 KO hepatocytes. Indeed, TSA and Parthenolide-treated hepatocytes showed increased levels of FXR, and reduced levels of CYP7A1, HDAC4, TNFα, TRAIL and Bax suggesting a less toxic effect of bile acids as a results of specific HDAC inhibition, resulting in the attenuation of the Phb1 KO hepatocytes apoptotic response. Importantly, Parthenolide exerts a protective effect from the liver injury after BDL in Phb1 KO mice. Indeed, Parthenolide treatment results in a reduction of the mortality rate of this mice after BDL associated with a lower apoptotic response as revealed by a reduction of necrotic areas, Tunel-staining, as well as decreased ALT (8431±957 vs.4225±210 U/L) and AST (4805±300 vs.2242±438 U/L) activities compared to control Phb1 KO mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MCOPPB, MCOPPB 3HCl, MCOPPB Trihydrochloride, MCOPPB triHydrochloride, MCOPPB trihydrochlride, Inhibitor, OpioidReceptor, Opioid Receptor, inhibit

Compound Identifiers

PubChem CID

25208093