MCC950 sodium

SKU: orb1225499

Description

MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3; blocks NLRP3 induced ASC oligomerization, does not block K+ efflux, Ca2+ flux or NLRP3-ASC interactions; reduces interleukin-1β (IL-1β) production in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (EAE), rescues neonatal lethality in mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome.

Key Properties

• CAS Number: 256373-96-3
• MW: 426.4618
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₃N₂NaO₅S
• SMILES: CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]
• Target: NOD
• Solubility: H2O: ≥ 30 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP-456773 sodium | CRID3 sodium salt | MCC-950 sodium | CP456773 sodium | CRID-3 sodium salt

Quick Database Links

Gene Symbol

NOD