Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate

SKU: orb1980115

Description

This fluorogenic substrate, Mca-SEVNLDAEFR-K(Dnp)-RR-NH2, is designed for quantifying β-secretase (BACE1) activity. Upon cleavage, it releases the fluorescent 7-methoxycoumarin-4-acetyl (Mca) group (Ex/Em 328/420 nm), enabling sensitive measurement of enzyme kinetics in both in vitro and cell-based assays for Alzheimer's disease research.

Key Properties

• Target: Others
• Molecular Weight: 2001.08
• Formula: C₈₆H₁₂₅N₂₇O₂₉.XC₂H₄O₂
• SMILES: N=C(N)NCCC[C@@H](C(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCNC1=C(C=C(C=C1)[N+]([O-])=O)[N+]([O-])=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC(CC(C3=CC=C(OC)C=C3O4)=CC4=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171361275