MC4171

SKU: orb2278202

Description

MC4171 is a potent and selective small molecule inhibitor of the lysine acetyltransferase KAT8. It exhibits antiproliferative effects in cellular assays and is a valuable chemical probe for investigating KAT8's role in oncology research, including in vitro and in vivo cancer models.

Research Area

Epigenetics & Chromatin

Key Properties

• MW: 357.36
• Purity: 99.56% (May vary between batches)
• Formula: C₂₁H₁₅N₃O₃
• SMILES: O=C1/C(C(C2=CC=CC=C2)=NN1C3=CC=C(C(O)=O)C=C3)=C\C4=CC=CN4
• Target: Histone Acetyltransferase
• Solubility: DMSO:20 mg/mL (55.97 mM)

Bioactivity

• Target IC50:
  A549 cells:33.0 ± 5.7 μM|HCT116 cells:46.6 ± 11.5μM|H1299 cells:41.6 ± 6.8 μM|HT29 cells:54.0 ± 10.9 μM|U-937 cells:51.7 ± 9.5 μM
• In Vitro:
  KAT8 inhibitory activity and selectivity of MC4171, yielding an IC50 value of 8.2 μM. Exposed each cell line for 72 h to increasing doses (10, 25, 50, 100 μM) of MC4171 and measured cell viability through the MTT-based colorimetric assay. HT29 IC50=54.0 ± 10.9 μM; HCT116 IC50=46.6 ± 11.5μM; H1299 IC50=41.6 ± 6.8 μM; A549 IC50=33.0 ± 5.7 μM; U937 IC50=51.7 ± 9.5 μM
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HistoneAcetyltransferase, Histone Acetyltransferase, MC 4171, MC-4171, KAT8

Compound Identifiers

PubChem CID

168475934