MC3482

SKU: orb1709182

Description

MC3482 is a potent and selective small molecule inhibitor of the mitochondrial deacylase SIRT5. It is a valuable chemical probe for investigating SIRT5's roles in metabolism, cancer, and heart failure, facilitating both in vitro enzymatic studies and cellular pathway analysis.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2922280-86-0
• MW: 618.68
• Purity: 98.00% (May vary between batches)
• Formula: C₃₃H₃₈N₄O₈
• SMILES: [C@H](C(NC1=CC=CC=C1)=O)(NC(OCC2=CC=CC=C2)=O)CCCCNC(CC[C@H](NC(OCC3=CC=CC=C3)=O)C(O)=O)=O
• Target: Sirtuin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.47 mM);DMSO:145 mg/mL (234.37 mM)

Bioactivity

• In Vitro:
  MC3482 selectively inhibits the desuccinylating activity of sirtuin5 (SIRT5) at a concentration of 50 μM, without altering SIRT5's intracellular expression levels. Both autophagy and mitophagy are enhanced in cells with silenced SIRT5 and in wild-type cells treated with MC3482, whereas these processes are diminished in cells overexpressing SIRT5.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MC3482, MC-3482, MC 3482, SIRT5

Compound Identifiers

PubChem CID

134694957