MC2590

SKU: orb1744105

Description

MC2590 is a potent and selective HDAC inhibitor targeting isoforms 1-3, -6, -8, and -10. It induces cell cycle arrest and apoptosis, making it a valuable tool for cancer research in both cellular and animal models to study epigenetic mechanisms and therapeutic potential.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2284460-01-9
• MW: 347.37
• Purity: 99.14% (May vary between batches)
• Formula: C₂₀H₁₇N₃O₃
• SMILES: C(C(NC=1C=CC(C=CC(NO)=O)=NC1)=O)C=2C3=C(C=CC2)C=CC=C3
• Target: HDAC,Apoptosis

Bioactivity

• Target IC50:
  HDAC4:2.73 μM|HCT116 cells:0.07 μM|HDAC1:0.098 μM|A549 cells:0.32 μM|HDAC7:2.06 μM|HDAC2:0.156 μM|HDAC5:1.35 μM|HDAC9:2.79 μM|HDAC10:0.071 μM|HDAC8:0.047 μM|HDAC6:0.015 μM|HDAC3:0.039 μM|K562 cells:0.05 μM|HDAC11:3.98 μM
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• In Vitro:
  MC2625/MC2590 (Compound 5e), over 72 hours, inhibits colorectal cancer cells HCT116 (IC50=0.07 μM), lung adenocarcinoma cells A549 (IC50=0.32 μM), and chronic myeloid leukemia cells K562 (IC50=0.05 μM) .At concentrations of 1 and 5 μM over 24 and 48 hours, MC2625/MC2590 induces G2/M cell cycle arrest . At concentrations of 1 and 5 μM over 24 and 48 hours, MC2625/MC2590 induces excessive acetylation activity of H3K9/14, increases acetylated-α-tubulin levels, and significantly upregulates p21 protein .At concentrations of 1 and 5 μM over 48 hours, MC2625/MC2590 increases mRNA expression of p21, BAX, and BAK, downregulates cell cycle proteins D1 and BCL-2, and modulates pro-apoptotic and anti-apoptotic microRNAs to induce apoptosis .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HDAC, Apoptosis

Compound Identifiers

PubChem CID

172878711