MC-VA-PAB-Exatecan

SKU: orb2944303

Description

MC-VC-PAB-Exatecan is a cleavable linker-payload complex used to synthesize Antibody-Drug Conjugates (ADCs). This key intermediate, incorporating the potent topoisomerase I inhibitor exatecan, is widely employed in preclinical research for developing targeted cancer therapies, as evidenced by its use in in vitro cytotoxicity assays and in vivo xenograft model studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2680543-57-9
• MW: 948.00
• Formula: C₅₀H₅₄FN₇O₁₁
• SMILES: O=C(C=C1)N(CCCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC2=CC=C(COC(N[C@@H]3C4=C(CN5C6=CC7=C(COC([C@@]7(CC)O)=O)C5=O)C6=NC8=CC(F)=C(C)C(CC3)=C48)=O)C=C2)=O)=O)=O)C1=O
• Target: ADC Linker

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ADC Linker