MC-Val-Ala-PAB-PNP

SKU: orb1307358

Description

MC-Val-Ala-PAB-PNP is a protease-cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). This chemical tool enables the targeted delivery of cytotoxic payloads in both in vitro and in vivo cancer research, facilitating the study of novel therapeutic strategies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1639939-40-4
• MW: 651.66
• Purity: 96.04% (May vary between batches)
• Formula: C₃₂H₃₇N₅O₁₀
• SMILES: O(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN2C(=O)C=CC2=O)=O)[C@H](C)C)=O)C)=O)C=C1)=O)C3=CC=C(N(=O)=O)C=C3
• Target: PROTAC Linker,ADC Linker
• Solubility: DMSO:50 mg/mL (76.73 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.07 mM)

Bioactivity

• In Vitro:
  ADCs consist of an antibody attached to an ADC cytotoxin through an ADC linker.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cleavable, ADC Linker, ADCLinker, ADC Linkers, Antibody-drug conjugates linkers, inhibit, Inhibitor, MCValAlaPABPNP, MC-Val-Ala-PAB-PNP, MC Val Ala PAB PNP

Compound Identifiers

PubChem CID

100029269