MC-EVCit-PAB-MMAE

SKU: orb2278128

Description

MC-EVCit-PAB-MMAE (Linker-Payload 11) is a cleavable linker-payload complex for constructing antibody-drug conjugates (ADCs). It releases the potent antimitotic agent MMAE, a tubulin inhibitor, upon cleavage. This payload is widely used in ADC research for targeted cancer therapy, enabling both in vitro cytotoxicity studies and in vivo efficacy evaluations in preclinical models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2873452-49-2
• MW: 1445.74
• Formula: C₇₃H₁₁₂N₁₂O₁₈
• SMILES: [C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCN4C(=O)C=CC4=O)=O)CCC(O)=O)=O)[C@H](C)C)=O)CCCNC(N)=O)=O)C=C3)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
• Target: Microtubule Associated,Drug-Linker Conjugates for ADC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168432140