MB710

SKU: orb1685250

Description

MB710 is an amino benzothiazole-based compound that acts as a selective stabilizer of the p53-Y220C mutant protein by binding its surface pocket. This mechanism has demonstrated anticancer activity in vitro, supporting its use in oncology research for studying p53 reactivation strategies.

Research Area

Cell Biology

Key Properties

• CAS Number: 2230044-57-0
• MW: 457.29
• Purity: 99.02% (May vary between batches)
• Formula: C₁₆H₁₆IN₃O₃S
• SMILES: O=C(O)C=1C(O)=C(I)C(=C2SC(=NC21)N(CC)CC)N3C=CC=C3
• Target: MDM-2/p53,Mdm2,p53
• Solubility: DMSO:80 mg/mL (174.94 mM)

Bioactivity

• In Vitro:
  MB710 (0-200 μM; 72 hours) shows relatively low toxicity against all tested cell lines at concentrations up to 60 μM, while showing initial selective viability reduction at higher concentrations . MB710 (72 hours) treats cancer cell lines NUGC3, NUGC4, WI38 and SW1088, with IC 50 s of 90, 120, >120, >120 μM, respectively . MB710 (0-120 μM; 72 hours; HUH-7 cells) shows stronger cytotoxic effects in presence of p53-Y220C . Cell Viability Assay Cell Line: NUGC3 (mutant p53 Y220C), HUH-7 (mutant p53 Y220C), NUGC4 (p53 WT), HUH-6 cells (p53 WT) Concentration: 0-200 μM Incubation Time: 72 hours Result: Showed relatively low toxicity against all cell lines tested at concentrations up to 60 μM. NUGC3 was the most sensitive cell line.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MB 710, MB710, MB-710

Compound Identifiers

PubChem CID

133082032