MB-07729

SKU: orb1709188

Description

MB-07729 is a potent, species-selective, non-competitive inhibitor of fructose-1,6-bisphosphatase, demonstrating nanomolar IC50 values in human, monkey, and rat assays. This small molecule is a valuable research tool for investigating gluconeogenesis inhibition in diabetes research, applicable in both in vitro enzymatic studies and in vivo metabolic models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 882755-95-5
• MW: 330.3
• Purity: 99.23% (May vary between batches)
• Formula: C₁₂H₁₅N₂O₅PS
• SMILES: C(C(C)(C)C)(=O)C1=C(N=C(N)S1)C=2OC(P(=O)(O)O)=CC2
• Target: Phosphatase
• Solubility: DMSO:50 mg/mL (151.38 mM)

Bioactivity

• Target IC50:
  Rat:189 nM |Rat:189 nM|Monkey:121nM |Monkey:121nM|Human:31 nM |Human:31 nM
• In Vitro:
  MB-07729 is a potent fructose 1,6-bisphosphatase (FBPase) noncompetitive inhibitor with IC50 values of 31, 121, and 189 nM for human, monkey, and rat, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

monkey, MB07729, MB-07729, MB 07729, human, Fructose-1,6-bisphosphate (FBPase), rat

Compound Identifiers

PubChem CID

24770594