Mavorixafor

SKU: orb1296155

Description

Mavorixafor (AMD-070) is a potent and selective CXCR4 antagonist with a 13 nM IC₅₀ for receptor binding. It effectively blocks T-tropic HIV-1 replication in vitro, showing IC₅₀ values of 1 nM and 9 nM in MT-4 cells and PBMCs, respectively. Its research applications extend to oncology and immunology, including studies on cancer metastasis and stem cell mobilization.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 558447-26-0
• MW: 349.47
• Purity: 98.56% (May vary between batches)
• Formula: C₂₁H₂₇N₅
• SMILES: N(CC=1NC=2C(N1)=CC=CC2)(CCCCN)[C@@H]3C=4C(CCC3)=CC=CN4
• Target: HIV Protease,CXCR
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (5.72 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:44 mg/mL (125.9 mM);DMSO:44 mg/mL (125.9 mM)

Bioactivity

• Target IC50:
  HIV-1 (NL4.3 strain):3 nM (in MT-4 cells)|HIV-1 (NL4.3 strain):26 nM (IC90, in PBMCs)|HIV-1 (NL4.3 strain):1 nM (in MT-4 cells)|HIV-1 (NL4.3 strain):9 nM (in PBMCs)|[125I]-SDF-CXCR4:13 nM
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• In Vivo:
  AMD-070 (2 mg/kg, p.o.) markedly decreases the quantity of metastatic lung nodules in mice and reduces human Alu DNA expression without causing weight loss .
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• In Vitro:
  Mavorixafor (6.6 µM) significantly decreases the anchorage-dependent growth, migration, and matrigel invasion of the B88-SDF-1 cells . Mavorixafor shows no effect on other chemokine receptors (CCR1, CCR2b, CCR4, CCR5, CXCR1, and CXCR2) .
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• Cell Research:
  Cells are seeded on a 96-well plate at 5 × 10^3 cells/well in DMEM containing 10% FCS. Twenty-four hours later, the cells are treated with or without 2 µM AMD3100 or 6.6 µM AMD-070. After 24 or 48 h, the number of cells is quantified by an assay using MTT .
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• Animal Research:
  BALB/c nude mice are maintained under pathogen-free conditions. The experiments are initiated when the mice are 8 weeks of age. Briefly, the cells are inoculated into the blood vessels of nude mice (1× 10^6). These mice are sacrificed at day 49. The presence or absence of distant metastases is confirmed by hematoxylin and eosin (H&E) staining. For experimental chemotherapy, the mice are treated by the daily oral administration of 0.2 mL of saline for a vehicle or the same volume of AMD-070 (2 mg/kg) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CXCR4, CXCR, CXC chemokine receptors, AMD 070, AMD070, AMD-070, inhibit, Inhibitor, HIV, Mavorixafor, Human immunodeficiency virus

Compound Identifiers

PubChem CID

11256587