Matrine

SKU: orb1304908

Description

Matrine is a natural alkaloid derived from Sophora plants that functions as a kappa opioid receptor (KOR) agonist. It is a valuable research tool for studying KOR signaling in neuropharmacology, pain research, and addiction studies, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 519-02-8
• MW: 248.36
• Purity: >98%
• Formula: C₁₅H₂₄N₂O
• SMILES: O=C1N2[C@@]([C@@]3([C@@]4([C@](C2)(CCCN4CCC3)[H])[H])[H])(CCC1)[H]
• Target: HSP (Heat shock protein)
• Solubility: Soluble in Water (up to at least 25 mg/ml)

Bioactivity

• In Vivo:
  In mice, the median lethal dose (LD50) of Matrine administered via intraperitoneal injection is 157 mg/kg.
• In Vitro:
  In human non-small cell lung cancer A549 and hepatocellular carcinoma SMMC-7721 cells, Matrine inhibits cell growth. Particularly, in A549 cells, Matrine induces apoptosis by reducing the Bcl-2 / Bax protein ratio.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Matridin-15-one

Compound Identifiers

PubChem CID

285698