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Matrine

SKU: orb1304908

Description

Matrine is a natural alkaloid derived from Sophora plants that functions as a kappa opioid receptor (KOR) agonist. It is a valuable research tool for studying KOR signaling in neuropharmacology, pain research, and addiction studies, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number519-02-8
MW248.36
Purity>98%
FormulaC15H24N2O
SMILESO=C1CCCC2C3CCCN4CCCC(CN12)C34
TargetHSP (Heat shock protein)
SolubilitySoluble in Water (up to at least 25 mg/ml)

Bioactivity

In Vivo
In mice, the median lethal dose (LD50) of Matrine administered via intraperitoneal injection is 157 mg/kg.
In Vitro
In human non-small cell lung cancer A549 and hepatocellular carcinoma SMMC-7721 cells, Matrine inhibits cell growth. Particularly, in A549 cells, Matrine induces apoptosis by reducing the Bcl-2 / Bax protein ratio.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Matridin-15-one

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Key Properties

No computed properties available.

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Matrine (orb1304908)

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Available Sizes

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10 mg
$ 160.00
50 mg
$ 240.00
DispatchUsually dispatched within 3-5 working days
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