Matairesinol

SKU: orb1684423

Description

Matairesinol is a dietary phytolignan with demonstrated anti-cancer, anti-angiogenic, and anti-fungal properties. Research indicates its anti-osteoporotic potential is linked to inhibiting osteoclastogenesis via p38/ERK-NFATc1 signaling, as shown in cellular studies. This compound is a valuable tool for investigating bone metabolism, oncology, and angiogenesis in experimental models.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 580-72-3
• MW: 358.39
• Purity: 99.76% (May vary between batches)
• Formula: C₂₀H₂₂O₆
• SMILES: COc1cc(C[C@H]2COC(=O)[C@@H]2Cc2ccc(O)c(OC)c2)ccc1O
• Target: ROS,ATPase,Endogenous Metabolite,p38 MAPK

Bioactivity

• In Vivo:
  METHODS: A rat sepsis model was established by CLP surgery. On this basis, the rats were given Matairesinol (5, 10, 20 mg/kg, oral administration). Subsequently, blood and IHC were performed to calculate the number of Caspase-3 positive cells and TUNEL staining was performed to detect tissue apoptosis. RESULTS Matairesinol (>5 mg/kg) inhibited the production of S100β, GFAP and NSE; at the same time, the use of Matairesinol on the basis of CLP reduced the damage of CLP to brain tissue and neurons; Matairesinol (>5 mg/kg) significantly inhibited the expression of Caspase-3 and inhibited cell apoptosis.
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• In Vitro:
  METHODS: Antiproliferative effect of matairesinol on human pancreatic cancer cells. Cell proliferation was analyzed in PANC-1 and MIA PaCa-2 using different matairesinol treatments (0, 5, 10, 20, 40, 80 and 100 μM). RESULTS The 80 μM concentration of matairesinol inhibited proliferation by 48% in PANC-1 cells and inhibited cellular appreciation by 50% in MIA PaCa-2 cells. METHODS: Immunoblotting images of PCNA were analyzed in PANC-1 and MIA PaCa-2 cells treated with matairesinol (0, 20, 40, and 80 μM), and the inhibitory effect of matairesinol on globule formation was assessed in a three-dimensional (3D) environment using a droplet assay. RESULTS Treatment with matairesinol (80 μM) reduced PCNA expression by 30% and 33% in both PC cell lines; in PANC-1 cells, the relative total area of formed spheroids was reduced by 78% in PANC-1 cells (p < 0.05) and 61% in MIA PaCa-2 cells (p < 0.01). Translated with DeepL.com (free version)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROS, p38MAPK, p38, p38 MAPK, ATPase, Matairesinol

Compound Identifiers

PubChem CID

119205