MAT2A-IN-20

SKU: orb2945810

Description

MAT2A-IN-20 (Compound A49) is a potent, sub-50 nM inhibitor of methionine adenosyltransferase 2A (MAT2A) and a weaker inhibitor of human UGT1A1 (IC50 = 28.45 µM). This small molecule has demonstrated antitumor efficacy in mouse models, supporting its use in oncology research for studying methionine metabolism and cancer cell proliferation in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 3018834-98-2
• MW: 522.503
• Formula: C₂₆H₂₄F₂N₆O₄
• SMILES: O=C1C(=NC=2C=NC(=NC2N1C3=CC=C(OC(F)F)C=C3)OCC)C=4C=CC=5N=C(N(C5C4)C)C(O)(C)C
• Target: Methionine Adenosyltransferase (MAT)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166523761