MASTL/Aurora A-IN-1

SKU: orb3027579

Description

MASTL/Aurora A-IN-1 is a dual inhibitor targeting MASTL and Aurora A kinases with IC50 values of 0.56 μM and 0.16 μM, respectively. MASTL/Aurora A-IN-1 exhibits broad-spectrum anticancer activity across the NCI-60 cancer cell line panel, particularly against SR (leukemia), K-562 (leukemia), MDA-MB-435 (melanoma), MOLT-4 (leukemia), and SK-MEL-2 (melanoma), with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 μM, respectively. By inhibiting Aurora A and MASTL kinases, MASTL/Aurora A-IN-1 induces G2/M cell cycle arrest, thereby inhibiting cancer cell proliferation. MASTL/Aurora A-IN-1 is applicable to cancer research, particularly for tumors with mitotic abnormalities.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 321945-24-8
• MW: 310.41
• Purity: 99.53% (May vary between batches)
• Formula: C₁₈H₁₈N₂OS
• SMILES: N#CC1=C(SC2=C1CCCC2)NC(=O)CCC=3C=CC=CC3
• Target: Aurora Kinase,Serine/threonin kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Aurora Kinase,Serine/threonin kinase