Maropitant citrate

SKU: orb1694661

Description

Maropitant citrate is a selective NK-1 receptor antagonist that inhibits substance P, effectively preventing emesis in dogs and cats. It is widely used in veterinary research for in vivo antiemetic studies and in vitro investigations of neurokinin receptor pharmacology.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 359875-09-5
• MW: 678.81
• Purity: 98.91% (May vary between batches)
• Formula: C₃₈H₅₀N₂O₉
• SMILES: C(CC(O)=O)(CC(O)=O)(C(O)=O)O.C([C@H]1[C@@H](NCC2=C(OC)C=CC(C(C)(C)C)=C2)C3CCN1CC3)(C4=CC=CC=C4)C5=CC=CC=C5.O
• Target: Neurokinin receptor

Bioactivity

• Target IC50:
  NK1R:
• In Vivo:
  Maropitant citrate 1 and 2 mg/kg were injected subcutaneously into Rhode Island red hens. Blood samples were collected within 36 hours after administration. The mean maximum plasma concentration, the time to reach the maximum concentration and the elimination half-life were 915.6 ng/ml and 1195.2 ng/ml, 0.49 h and 1.6 h, and 8.47 h and 8.58 h, respectively. Treatment of ulcerative dermatitis (UD) mice with Maropitant citrate (1 mg/kg) significantly reduced the size of UD lesions in mice.
• In Vitro:
  Maropitant citrate is a synthetic neurokinin-1 receptor antagonist.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Neurokininreceptor, Neurokinin receptor

Compound Identifiers

PubChem CID

204107