MARK4 inhibitor 1

SKU: orb1218385

Description

MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2271081-58-2
• MW: 390.4
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₈N₆O₃
• SMILES: O=C(C1=CN(CC2=CC=C(OC)C=C2)N=N1)N\N=C3C4=CC=CC(C)=C4NC\3=O
• Target: MARK4
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: MCF-7, MDA-MB-435s and HepG2 cells. Concentration: 0-200 μM. Incubation time: 24 and 48 h. Result: Decreased the viability of these cells in a concentration dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MARK4