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Marimastat

SKU: orb1226126

Description

A broad spectrum MMP inhibitor for MMP9/1/2/14/7 with IC50 of 3/5/6/9/13 nM, respectively.Lung Cancer Phase 3 Clinical(In Vitro):Marimastat (BB2516) (1 μM) shows inhibition of vascular outgrowth, and selectively affects angiogenesis.(In Vivo):Animals receiving chemoradiation + Marimastat (BB2516) (8.7 mg/kg) have statistically significant delayed growth, compared to animals receiving chemoradiation alone. Marimastat (BB2516) may work in combination with chemotherapy and radiation to inhibit tumor growth.

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Key Properties

CAS Number154039-60-8
MW331.4079
Purity>98% (HPLC)
FormulaC15H29N3O5
SMILESO=C(N[C@@H](C(C)(C)C)C(NC)=O)[C@H](CC(C)C)[C@H](O)C(NO)=O
TargetMMP
SolubilityDMSO: ≥ 140 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

BB-2516 | TA-2516

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Marimastat (orb1226126)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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% Tween 80 +
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Available Sizes

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200 mg
500 mg
5 mg
$ 140.00
10 mg
$ 200.00
25 mg
$ 330.00
50 mg
$ 520.00
100 mg
$ 750.00