MAPK-IN-5

SKU: orb3136200

Description

MAPK-IN-5 is a potent inhibitor of MAPK, with an IC50 value of 1.35 μM in HeLa cells. It induces ROS-mediated DNA damage and mitochondrial apoptosis (apoptosis) via the MAPK pathway. MAPK-IN-5 significantly inhibits colony formation in HeLa cells, reduces viable cell numbers, suppresses cell migration, and arrests the cell cycle at the G2/M phase. It is applicable in cervical cancer research.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 2579683-39-7
• MW: 594.58
• Formula: C₃₀H₂₉F₃N₆O₄
• SMILES: FC(F)(F)C1=CC=C(C=C1)CN2N=NC(=C2)C=3C=CC=C(C3)NC=4N=CN=C5C=C(OCCOC)C(OCCOC)=CC54
• Target: Apoptosis,Caspase,ROS,PARP,Bcl-2 Family,p38 MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,ROS,PARP,Bcl-2 Family,p38 MAPK