MAP855

SKU: orb1686039

Description

MAP855 is a potent, selective, and orally bioavailable ATP-competitive inhibitor of MEK1/2, with IC₅₀ values of 3 nM and 5 nM in biochemical and cellular (pERK) assays, respectively. It effectively inhibits both wild-type and mutant MEK isoforms and is a valuable tool for investigating the MAPK pathway in cancer and other disease models, both in vitro and in vivo.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1660107-77-6
• MW: 564.97
• Formula: C₂₈H₂₃ClF₂N₆O₃
• SMILES: [H][C@@]1(CCN(C[C@@H]1F)C(=O)CO)n1c(C)nc2cnc3cc(F)c(cc3c12)-c1ccc(Oc2ncccn2)cc1Cl
• Target: Others,ERK,MEK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

90647159