MAO-B-IN-46

SKU: orb3136680

Description

MAO-B-IN-46 (Compound 16) is a selective human MAO-B inhibitor with an IC50 of 26.8 nM, while showing weaker activity against hMAO-A (IC50: 7.2054 μM). This compound, also referred to as MAO-B-IN-46 (Compound 8), acts as an α-amylase inhibitor with an IC50 of 19.46 μM. It demonstrates certain neuroprotective properties and exhibits no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS radicals, with IC50 values of 17.86 and 17.71 μM, respectively. MAO-B-IN-46 is applicable in research on neurodegenerative diseases like Parkinson's, diabetes, and conditions related to oxidative stress.

Research Area

Metabolism Research, Neuroscience

Key Properties

• CAS Number: 27052-20-6
• MW: 256.68
• Formula: C₁₅H₉ClO₂
• SMILES: O=C(C=1OC=2C=CC=CC2C1)C3=CC=C(Cl)C=C3
• Target: Monoamine Oxidase,Amylase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Monoamine Oxidase,Amylase