MAO A/HSP90-IN-2

SKU: orb1944244

Description

MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90. This compound enhances HSP70 expression, diminishes HER2 and phospho-Akt levels, downregulates IFN-γ-induced PD-L1 expression in GL26 cells, and demonstrates efficacy against Temozolomide-sensitive and -resistant GBM cells, colon cancer, leukemia, and non-small cell lung cancer, possibly impeding tumor immune evasion.

Research Area

Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 2927489-99-2
• MW: 458.98
• Formula: C₂₅H₃₁ClN₂O₄
• SMILES: C(N(CC)C1=CC(Cl)=C(OCCCN(CC#C)C)C=C1)(=O)C2=CC(C(C)C)=C(O)C=C2O
• Target: Monoamine Oxidase,HSP

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Monoamine Oxidase,HSP