Manganese(salen) chloride

SKU: orb1303215

Description

EUK-8, or Manganese(salen) chloride, is a synthetic mimetic of superoxide dismutase and catalase enzymes. This antioxidant compound scavenges reactive oxygen species and has been shown in research to mitigate acute lung injury in endotoxemic swine models, supporting its study in oxidative stress-related pathologies.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 53177-12-1
• MW: 356.69
• Purity: 99.52% (May vary between batches)
• Formula: C₁₆H₁₄ClMnN₂O₂
• SMILES: [Cl-].[Mn+3].[O-]c1ccccc1C=NCCN=Cc1ccccc1[O-]
• Target: Reactive Oxygen Species,CAT,ROS
• Solubility: DMSO:2.5 mg/mL (7.01 mM)

Bioactivity

• In Vivo:
  Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant . In Wild-type (WT) and harlequin (Hq) B6CBA male and female mice, this treatment prevented myocardial oxidant damage, improved survival, prevented functional and geometrical deterioration, and attenuated necrotic and apoptotic cell death, as well as cardiac hypertrophy and fibrosis. This antioxidant treatment protected both the oxidative stress-prone Hq mouse model and WT mice against pressure overload-induced maladaptive left ventricular remodeling and cardiac decompensation, suggesting its potential as a novel therapeutic tool for human heart failure.
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• In Vitro:
  Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, completely blocking β-AP-induced free radical accumulation and lipid peroxidation .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, mimetic, Inhibitor, Manganese(salen), Manganese(salen) Chloride, Manganese(salen) chloride, EUK 8, EUK8, EUK-8, dismutase, catalase, antioxidant, superoxide, scavenging, Reactive Oxygen Species, oxyradical

Compound Identifiers

PubChem CID

171249