MALT1 inhibitor MI-2

SKU: orb1305618

Description

MI-2 is a potent, irreversible small molecule inhibitor of MALT1 protease. It is a valuable research tool for studying NF-κB signaling in immunology and oncology, with utility in both cellular assays and in vivo models of B-cell lymphomas.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 1047953-91-2
• MW: 455.72
• Purity: 99.87% (May vary between batches)
• Formula: C₁₉H₁₇Cl₃N₄O₃
• SMILES: COCCOc1nc(-c2ccc(Cl)c(Cl)c2)n(n1)-c1ccc(NC(=O)CCl)cc1
• Target: MALT
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.39 mM);DMSO:55 mg/mL (120.69 mM);Ethanol:9.1 mg/mL (19.97 mM)

Bioactivity

• Target IC50:
  MALT1:5.84 μM
• In Vivo:
  MI-2 demonstrates excellent cellular permeability and inhibits the function of MALT1 in the ABC-DLBCL cell lines. It selectively inhibits the growth of MALT1-dependent cell lines, with GI50 values of 0.2, 0.5, 0.4, and 0.4 μM in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells, respectively. Conversely, ABC-DLBCL cell lines not dependent on MALT1, such as U2932 and HLY-1, along with two types of GCB-DLBCL cell lines, exhibit resistance to MI-2.
• In Vitro:
  Daily intraperitoneal injection of 25 mg/kg MI-2 effectively inhibits the growth of TMD8 and HBL-1 ABC-DLBCL xenografts, while it has no effect on the growth of OCI-Ly1 tumors.
• Cell Research:
  Cell proliferation is determined by ATP quantification using a luminescent method and trypan blue dye exclusion. Standard curves for each cell line are calculated by plotting the cell number (determined using trypan blue) against their luminescence values, and cell number is calculated accordingly. Cell viability in drug-treated cells is normalized to their respective controls (fractional viability), and results are given as 1-fractional viability. CompuSyn software is used to determine GI25 and GI50 values.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mucosa associated lymphoid tissue lymphoma translocation gene 1, inhibit, MI2, MI-2, MI 2, MI 2 (MALT1 inhibitor), MALT1, MALT1 inhibitor, MALT1 inhibitor MI 2, MALT1 inhibitor MI2, MALT-1 inhibitor MI-2, MALT1 inhibitor MI-2, Inhibitor

Compound Identifiers

PubChem CID

45942672