Malic enzyme inhibitor ME1

SKU: orb1709199

Description

Malic enzyme inhibitor ME1 is a potent and specific small molecule inhibitor of Malic enzyme, exhibiting an IC50 of 0.15 μM. It is a valuable research tool for studying cancer metabolism, as it reduces cellular viability and metabolic activity in both in vitro and in vivo models of tumorigenesis.

Research Area

Metabolism Research, Metabolism Research; Pharmacology & Drug Discovery

Key Properties

• CAS Number: 522649-59-8
• MW: 351.4
• Purity: >99.99% (May vary between batches)
• Formula: C₂₀H₂₁N₃O₃
• SMILES: Oc1ccc(cc1)N1CCN(CC1)C1CC(=O)N(C1=O)c1ccccc1
• Target: Others,Fatty Acid Synthase
• Solubility: DMSO:250 mg/mL (711.44 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.39 mM)

Bioactivity

• Target IC50:
  Malic enzyme:0.15 μM
• In Vitro:
  In HCT116 cells and HT29 cells, Malic enzyme inhibitor ME1 (50 μM) significantly reduces the total number of cells and cell colonies in a dose-dependent manner. In MTS cells, Malic enzyme inhibitor ME1 decreases the viability and metabolic activities of cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ME 1, ME1, Malic enzyme, Malic enzyme inhibitor ME1

Compound Identifiers

PubChem CID

2936632