Mal-VC-PAB-DMEA-PNU-159682

SKU: orb2945785

Description

Mal-VC-PAB-DMEA-PNU-159682 is a cleavable linker-payload conjugate for constructing antibody-drug conjugates (ADCs). It incorporates the potent topoisomerase II inhibitor PNU-159682 and is used in research for synthesizing ADCs like Anti-CD22-NMS249, enabling the study of targeted cancer therapies in preclinical models.

Research Area

Molecular Biology

Key Properties

• CAS Number: 1178887-17-6
• MW: 1354.41
• Formula: C₆₆H₈₃N₉O₂₂
• SMILES: O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(COC(N(CCN(C(OCC5=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN6C(=O)C=CC6=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C5)=O)C)C)=O)=O)(O)C1)[C@H]7C[C@@]8(N9[C@](O[C@@]8([C@H](C)O7)[H])([C@@H](OC)OCC9)[H])[H]
• Target: Drug-Linker Conjugates for ADC,Topoisomerase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

130178149