Mal-PEG4-VC-PAB-EDA-PNU159682

SKU: orb2944309

Description

Mal-PEG4-VC-PAB-EDA-PNU159682 is a thiol-reactive linker-drug conjugate designed for constructing antibody-drug conjugates (ADCs). Its payload, PNU159682, is a potent DNA topoisomerase II inhibitor, enabling targeted cytotoxicity in cancer research, as demonstrated in both in vitro and in vivo preclinical ADC studies.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2571582-15-3
• MW: 1402.45
• Formula: C₆₇H₈₇N₉O₂₄
• SMILES: O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4OC)C[C@](C(NCCNC(OCC5=CC=C(NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCN6C(=O)C=CC6=O)=O)[C@@H](C)C)=O)CCCNC(N)=O)=O)C=C5)=O)=O)(O)C1)[C@H]7C[C@@]8(N9[C@](O[C@@]8([C@H](C)O7)[H])([C@@H](OC)OCC9)[H])[H]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168431258