Mal-Exatecan

SKU: orb2944552

Description

Mal-Exatecan (Mal-DX-8951) is a malonamide-conjugated derivative of the topoisomerase I inhibitor Exatecan, designed for constructing antibody-drug conjugates (ADCs). It is utilized in cancer research for evaluating ADC efficacy in both in vitro cytotoxicity assays and in vivo xenograft models.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3028213-52-4
• MW: 628.65
• Purity: 99.39% (May vary between batches)
• Formula: C₃₄H₃₃FN₄O₇
• SMILES: N(C(CCCCCN1C(=O)C=CC1=O)=O)[C@@H]2C3=C4C(C=5N(C4)C(=O)C6=C(C5)[C@](CC)(O)C(=O)OC6)=NC=7C3=C(CC2)C(C)=C(F)C7
• Target: ADC Cytotoxin,Topoisomerase
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (5.25 mM);DMSO:80 mg/mL (127.26 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Mal-DX8951, Mal-DX-8951

Compound Identifiers

PubChem CID

172913664