Magnesium Lithospermate B

SKU: orb1306531

Description

Magnesium Lithospermate B is a bioactive small molecule that ameliorates endothelial dysfunction in diabetes by activating eNOS and reducing oxidative stress. It also provides cardioprotection against ischemic injury via inhibition of the TAB1-p38 apoptosis pathway and has shown renoprotective effects in research models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 122021-74-3
• MW: 740.9
• Purity: 99.87% (May vary between batches)
• Formula: C₃₆H₂₈MgO₁₆
• SMILES: OC1=C2C=3C(C4=O[Mg+2]5(O=C(C=CC3C=C1)OC(CC6=CC(O)=C(O)C=C6)C(=O)[O-]5)[O-]C(=O)C(CC7=CC(O)=C(O)C=C7)O4)C(O2)C8=CC(O)=C(O)C=C8
• Target: ATPase,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.4 mM);H2O:19.23 mg/mL (25.95 mM);DMSO:100 mg/mL (134.97 mM)

Bioactivity

• In Vivo:
  magnesium lithospermate B (MLB), a bioactive ingredient extracted from Salvia miltiorrhiza, exerts neuroprotective effects in several central nervous system insults.administration of MLB significantly attenuated brain edema and neurological deficits after SAH.
• In Vitro:
  magnesium lithospermate B (MLB) dose-dependently inhibited the activation of microglia and reduced neuronal apoptosis. Western blot analysis showed that MLB decreased the expression of inflammatory cytokine TNF- and pro-apoptotic protein cleaved caspase-3. More importantly, MLB increased the expression of SIRT1, while inhibited the acetylation of NF-B. Furthermore, pretreatment with sirtinol (a selective inhibitor of SIRT1) reversed all the aforementioned effects of MLB after SAH.
• Animal Research:
  Adult male Sprague-Dawley rats were subjected to an endovascular perforation process to produce an SAH model. MLB was administrated intraperitoneally at 30min after SAH with a dose of 25mg/kg or 50mg/kg.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

diseases, caffeic, neuroin?ammation, miltiorrhizae, Magnesium Lithospermate B, tetramer, Salviae

Quick Database Links

Gene Symbol

ATPase,Others