Madecassoside

SKU: orb1222339

Description

Madecassoside is a pentacyclic triterpene extracted from Centella asitica (L.) with anti-inflammatory, anti-oxidative and anti-aging activities.

Key Properties

• CAS Number: 34540-22-2
• MW: 975.12
• Purity: >98% (HPLC)
• Formula: C₄₈H₇₈O₂₀
• SMILES: [C@@H]1([C@@H](CC[C@@]2(CC[C@@]3([C@@]4(C[C@H]([C@H]5[C@]([C@H]([C@@H](C[C@@]5([C@H]4CC=C3[C@H]12)C)O)O)(C)CO)O)C)C)C(=O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O)O)O)O)O)C)C
• Target: Others
• Solubility: DMSO : ≥ 9.8 mg/mL; 10.05 mM

Bioactivity

• In Vivo:
  Animal model: Focal cerebral ischemia reperfusion injury in Sprague Dawley rats. Dosage: 6, 12, 24 mg/kg. Administration: Intravenous injection. Result: Reduced neurological deficit, infarct area, brain damage and neuronal apoptosis. Animal model: Lipopolysaccharide-induced neurotoxicity in Sprague-Dawley rats. Dosage: 30-120 mg/kg for 14 days. Administration: Intraperitoneal injection. Result: Reduced LPS-induced cognitive impairment and imflammatory cytokine, promoted Nrf2 pathway at concentration of 120 mg/kg.
• In Vitro:
  Cell Viability Assay Cell line: HUVECs. Concentration: 10, 30, 100 μmol/L. Incubation time: 12 h. Result: Increased cell viability to 68.9% and 78.3%, with concentration of 30 and 100 μmol/L, respectively. Western blot analysis. Cell line: HUVECs. Concentration: 10, 30, 100 μmol/L. Incubation time: 12 h. Result: Inhibited phosphorylation in p38 MAPK.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Asiaticoside A

Quick Database Links

Gene Symbol

Others