Macozinone

SKU: orb1226412

Description

Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro; PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043.Bacterial Infection Phase 2 Clinical(In Vitro):Macozinone (PBTZ169) is highly potent against M. tuberculosis in vitro, ex vivo, and in vivo.

Key Properties

• CAS Number: 1377239-83-2
• MW: 456.484
• Purity: >98% (HPLC)
• Formula: C₂₀H₂₃F₃N₄O₃S
• SMILES: O=C1N=C(N2CCN(CC3CCCCC3)CC2)SC4=C([N+]([O-])=O)C=C(C(F)(F)F)C=C14
• Target: Antibacterial
• Solubility: DMSO: 6.4 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PBTZ169 | PBTZ-169

Quick Database Links

Gene Symbol

Antibacterial