MAC glucuronide phenol-linked SN-38

SKU: orb1987862

Description

This compound, a pH-sensitive prodrug linker conjugate of SN-38, acts as a DNA topoisomerase I inhibitor. It demonstrates cytotoxic activity in vitro, with IC50 values of 113 ng/mL in L540cy cells and 67 ng/mL in Ramos cells. Its design is relevant for developing antibody-drug conjugates (ADCs) in oncology research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2246380-69-6
• MW: 1091.06
• Formula: C₅₀H₅₄N₆O₂₀S
• SMILES: CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OCN(CCS(C)(=O)=O)C(=O)OCc3ccc(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)c(NC(=O)CN(C)C(=O)CCN4C(=O)C=CC4=O)c3)cc12
• Target: Drug-Linker Conjugates for ADC,PROTAC Linker

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139035092