MAC glucuronide α-hydroxy lactone-linked SN-38

SKU: orb1987710

Description

This cytotoxic drug linker incorporates a stabilized lactone form of the SN-38 metabolite, a potent topoisomerase I inhibitor. It demonstrates in vitro efficacy against hematological cancer cell lines such as L540cy and Ramos, with IC50 values of 99 and 105 ng/mL, respectively. This compound is a valuable tool for developing antibody-drug conjugates (ADCs) and studying targeted cancer therapies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2246380-70-9
• MW: 1091.06
• Formula: C₅₀H₅₄N₆O₂₀S
• SMILES: O=C1N2C(C=3C(C2)=C(CC)C=4C(N3)=CC=C(O)C4)=CC5=C1COC(=O)[C@]5(OCN(C(OCC6=CC(NC(CN(C(CCN7C(=O)C=CC7=O)=O)C)=O)=C(O[C@@H]8O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]8O)C=C6)=O)CCS(C)(=O)=O)CC
• Target: PROTAC Linker,Drug-Linker Conjugates for ADC

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

139035091