M77976

SKU: orb1707021

Description

M77976 is a selective, ATP-competitive PDK4 inhibitor with an IC50 of 648 µM. This compound is a research tool used in metabolic disease studies, including investigations into obesity and diabetes, to modulate glucose metabolism in cellular and animal models.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 394237-61-7
• MW: 296.32
• Purity: 99.43% (May vary between batches)
• Formula: C₁₇H₁₆N₂O₃
• SMILES: COc1ccc(cc1)-c1c(C)[nH]nc1-c1ccc(O)cc1O
• Target: PDK,Dehydrogenase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (13.5 mM);DMSO:100 mg/mL (337.47 mM)

Bioactivity

• Target IC50:
  PDK4:648 μM
• In Vitro:
  Binding to the ATP-binding pocket of PDK4, M77976 induces local conformational changes, resulting in complete disordering of the ATP lid. M77976 engages in hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306, and Thr358 of PDK4.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PDK4, M 77976, M77976, M-77976

Compound Identifiers

PubChem CID

764764