M6766

SKU: orb3172992

Description

M6766 is a selective and potent inhibitor of endoplasmic reticulum oxidoreductase 1α (ERO1α), exhibiting an IC50 of 1.4 uM and a KD of 1.1 uM. It also inhibits ERO1β with an IC50 of 7.2 uM. M6766 exerts its inhibitory effect by binding to the flavin adenine dinucleotide (FAD)-binding pocket of ERO1α. Functionally, M6766 suppresses granule secretion, αIIbβ3 integrin activation, Ca2+ mobilization, and platelet aggregation. It serves as a significant chemical probe for investigating the molecular pathways of arterial thrombosis and neurological disorders, such as ischemic stroke.

Key Properties

• CAS Number: 696628-90-7
• MW: 360.44
• Purity: 99.17% (May vary between batches)
• Formula: C₁₉H₁₆N₆S
• SMILES: N#CC=1C2=NC=3C=CC=CC3N2C(SC4=NN=CN4C)=C5C1CCCC5
• Target: Reactive Oxygen Species

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Reactive Oxygen Species