M435-1279

SKU: orb2900259

Description

M435-1279 is a UBE2T inhibitor. M435-1279 inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1.

Key Properties

• CAS Number: 1359431-16-5
• MW: 419.47
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₇N₃O₅S₂
• SMILES: NS(=O)(=O)c1ccc(NC(=O)c2c(O)c3c4CCCCc4sc3[nH]c2=O)cc1
• Target: E1
• Solubility: In Vitro: DMSO : 50 mg/mL (119.20 mM; Ultrasonic )

Bioactivity

• In Vivo:
  Animal model: BALB/C nude mice CDX model (MKN45 tumor size: 75–100 mm3). Dosage: 5 mg/kg/day. Administration: Intratumor injection for 18 days. Result: Slowed the tumor growth. Induced higher RACK1 proteins expression, and lower Ki-67 and β-catenin proteins expression in intratumor tumors.
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• In Vitro:
  Cell Viability Assay Cell line: HGC27, AGS, and MKN45 cells. Concentration: 0, 2, 4, 8, 16, 31 μM. Incubation time: 48 h. Result: Inhibited the cell growth. Cell Viability Assay Cell line: HGC27, AGS, and MKN45 cells. Concentration: 0, 4, 8, 12, 16, 20 μM. Incubation time: Result: Inhibited the cell viability with IC50s of 16.8, 11.88, 6.93, 7.76 μM in GES-1, HGC27, MKN45, AGS cells, respectively.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

E1