M3686

SKU: orb2944621

Description

M3686 (Compound 29) is a potent, selective TEAD1 inhibitor (IC50 = 51 nM) with weaker activity against TEAD3. It potently inhibits YAP-dependent transcription in NCI-H226 cells (IC50 = 0.06 µM) and demonstrates significant in vivo antitumor efficacy in NCI-H226 xenograft models, supporting research in Hippo pathway signaling and cancer.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2738550-24-6
• MW: 429.395
• Formula: C₂₁H₁₈F₃N₅O₂
• SMILES: CN1N=C2N(C=3C(C2=N1)=CC(C(=O)N4CC[C@H](O)C4)=CC3)C5=CC=C(C(F)(F)F)C=C5
• Target: YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166838233