m-Chlorophenylbiguanide hydrochloride

SKU: orb1305769

Description

m-Chlorophenylbiguanide hydrochloride is a potent and selective 5-HT3 receptor agonist (Ki: 0.002 µM) with additional affinity for the dopamine transporter. It is widely used in neuroscience research to investigate serotonin and dopamine systems in both in vitro receptor binding assays and in vivo behavioral studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2113-05-5
• MW: 248.11
• Purity: 99.89% (May vary between batches)
• Formula: C₈H₁₁Cl₂N₅
• SMILES: Cl.NC(N)=NC(=N)NC1=CC(Cl)=CC=C1
• Target: 5-HT Receptor
• Solubility: H2O:< 20 mg/mL (80.61 mM);DMSO:60 mg/mL (241.83 mM)

Bioactivity

• Target IC50:
  5-HT3:0.002 µM(Ki)|5-HT2:10 µM(Ki)|5-HT1:10 µM(Ki)
• In Vivo:
  m-Chlorophenylbiguanide hydrochloride induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 μM, respectively).m-Chlorophenylbiguanide hydrochloride induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg).

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HTReceptor, 5HT Receptor, 1-(3-Chlorophenyl)biguanidehydrochloride, 5-HT3, mChlorophenylbiguanide hydrochloride, m-Chlorophenylbiguanide Hydrochloride, m Chlorophenylbiguanide hydrochloride

Compound Identifiers

PubChem CID

2730228