[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)

SKU: orb3142585

Description

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. This compound significantly reduces weight loss in diet-induced obesity (DIO) mouse models and improves Loperamide-induced urinary dysfunction in wild-type mice. It is applicable in the study of neurokinin receptor-mediated diseases such as obesity, insulin resistance, and type 2 diabetes.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• Target: Neurokinin receptor
• CAS Number: 2770688-04-3
• MW: 819.99
• Formula: C₃₉H₆₅N₉O₁₀
• SMILES: [C@@H](CC1=CC=C(O)C=C1)(NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCCN)=O)C(N[C@H](C(NCC(N([C@H](C(N[C@@H](CCCC)C(N)=O)=O)CC(C)C)C)=O)=O)C(C)C)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Neurokinin receptor