LYP-IN-1

SKU: orb1691738

Description

LYP-IN-1 is a potent and selective inhibitor of lymphoid-specific tyrosine phosphatase (Ki=110 nM), showing strong activity in T-cell and mast cell studies. Its selectivity profile makes it a valuable research tool for investigating autoimmune disease mechanisms and immune signaling pathways in both cellular and animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1404436-51-6
• MW: 501.92
• Purity: 92.43% (May vary between batches)
• Formula: C₂₈H₂₀ClNO₆
• SMILES: OC(=O)c1cc2c(C#Cc3cccc(Cl)c3)c(oc2cc1O)-c1ccc(OCC(=O)NC2CC2)cc1
• Target: Phosphatase
• Solubility: DMSO:1.5 mg/mL (2.99 mM)

Bioactivity

• Target IC50:
  LYP:110 nM (Ki)|LYP:0.259 μM
• In Vitro:
  LYP-IN-1 demonstrates inhibitory effects on a spectrum of mammalian protein tyrosine phosphatases (PTPs), including SHP1, SHP2, PTP-Meg2, FAP1, and PTP-PEST, exhibiting IC50 values of 5 μM, 2.5 μM, 0.59 μM, 0.39 μM, and 0.8 μM, respectively. At a concentration of 15 μM, LYP-IN-1 enhances both basal and TCR-induced phosphorylation of ZAP-70 on Tyr319 in JTAg cells, as well as significantly promoting the activation of mouse double-positive (DP) thymocytes, evidenced by increased surface expression of CD69 and Nur77, markers indicative of T cell activation.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LYPIN1, LYP-IN-1, LYP IN 1

Compound Identifiers

PubChem CID

70673568